(British Approved Name Modified, US Adopted Name, rINNM) Drug Nomenclature Synonyms: HTF-919; SDZ-HTF-919; Tegaserod, maleato de BAN: Tegaserod Maleate [BANM] USAN: Tegaserod Maleate INN: Tegaserod Maleate [rINNM (en)] INN: Maleato de tegaserod [rINNM (es)] INN: Tégasérod, Maléate de [rINNM (fr)] INN: Tegaserodi Maleas [rINNM (la)] INN: Тегасерода Малеат [rINNM (ru)] Chemical name: 1-{[(5-Methoxyindol-3-yl)methylene]amino}-3-pentylguanidine maleate Molecular formula: C16H23N5O,C4H4O4 =417.5 CAS: 145158-71-0 (tegaserod); 189188-57-6 (tegaserod maleate) ATC code: A03AE02 Stability and compatibility. Crushed tablets of tegaserod were found to be stable in water, and apple juice the latter may mask the taste of the drug. Orangejuice, milk, or yogurt were not recommended as vehicles because of incomplete dissolution or uncertainty about stability. Adverse Effects The most common adverse effects of tegaserod are gastrointestinal disturbances including abdominal pain, diarrhoea, nausea, vomiting, and flatulence. Diarrhoea generally occurs within the first week of treatment Read more [...]

Brand Name Medicine: Zelmac Active Ingredient Medicine: tegaserod Indication: Treatment of irritable bowel syndrome in patients whose primary symptom is constipation Company Name: Novartis Pharmaceuticals Corporation Introduction Irritable bowel syndrome (IBS) sufferers report frequent diarrhea, constipation, or alternating bouts of both, plus bloating and abdominal pain. It is more than twice as common in women as in men. Although the exact cause of IBS is unknown, a disruption in colonic sensory and motor function appears to be a culprit, resulting in hypersensitivity. Lotronex (alosetron) was approved by the FDA to treat female IBS sufferers whose primary symptom is diarrhea. Now patients with IBS whose main complaint is constipation have reason for hope, too: Novartis Pharmaceuticals Corporation's new drug Zelmac (tegaserod). Studies have shown that Zelmac relieves pain and constipation in IBS patients. How It Works Zelmac belongs to a new chemical class of compounds which selectively target and act on 5-HT4 receptors in the gastrointestinal tract. These serotonin receptors are believed Read more [...]